Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum

Senem Yaman Tunç, Elif Ağaçayak, Şükrü Budak, Nurettin Tunç, Mehmet Sait İçen, Fatih Mehmet Fındık, Talip Gül

Bilgiler
Özet

Künye

Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum. Perinatoloji Dergisi 2015;23(3):S73 DOI: 10.2399/prn.15.S001084

Yazar Bilgileri

Senem Yaman Tunç¹,

Elif Ağaçayak¹,

Şükrü Budak²,

Nurettin Tunç³,

Mehmet Sait İçen¹,

Fatih Mehmet Fındık¹,

Talip Gül¹

Dicle Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilimdalı, Diyarbakır
Diyarbakır Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Diyarbakır
Fırat Üniversitesi Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Elazığ

Yazışma Adresi

Senem Yaman Tunç, Dicle Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilimdalı, Diyarbakır, [email protected]

Yayın Geçmişi

Gönderilme Tarihi: 30 Ağustos 2015

Son Revizyon Tarihi: 30 Ağustos 2015

Kabul Edilme Tarihi: 01 Eylül 2015

Erken Baskı Tarihi: 01 Ekim 2015

Çıkar Çakışması

Çıkar çakışması bulunmadığı belirtilmiştir.

Amaç

To investigate whether serum levels of neopterin, inflammatory markers including C-reactive protein (CRP), tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and oxidative status indicators were altered in patients with hyperemesis gravidarum (HG).

Yöntem

This cross-sectional study was performed on 30 pregnants with HG (mean age: 30.67±6.68) and 30 controls (mean age: 28.00±5.30). Demographic features, obstetric history, the Pregnancy Unique Quantification of Emesis/Nausea (PUQE) index were noted. Complete blood count, serum biochemical assay as well as measurement of levels of CRP, TNF-a, IL-6, total antioxidant status (TAS) and total oxidative status (TOS) were implemented. Groups were compared in terms of these parameters and whether there are any correlations between these parameters.

Bulgular

White blood cell count (p=0.013), platelet count (p=0.015), TOS (p<0.001), PUQE score (p<0.001) and frequency of positivity for urinary ketone bodies (p<0.001) were remarkably higher in HG. On the other hand, serum levels of lactate dehydrogenase, (p<0.001), sodium (p<0.001), potassium (p<0.001), chloride (p<0.001) and TAS (p<0.001) were higher in the control group. No difference was noted with respect to levels of neopterin, CRP, TNF-a and IL-6. In patients with HG, positive correlation was detected between TOS and serum levels of LDH, while TNF-a, IL-6 and neopterin were positively correlated with haemoglobin levels.

Sonuç

Our results reveal that oxidative stress and inflammation may be associated with HG. Elucidation of the pathophysiology and complex interaction between various inflammatory processes necessitates further trials on larger series.