Positive triple screening test results and chromosomal abnormalities in women less than 35 years of age

Triple screening test has a significant predictive value for detection of fetal Down's syndrome cases. in this study we evaluated the results of triple screening test for chromosomal abnormalities in women less than 35 years of age. We had 201 screen positive women for trisomy 21 at a cut off level 1/270 and 12 screen positive cases for trisomy 18 at a cut off level 1/100. Amniocentesis was performed for all. in cases with positive screen for trisomy 21 we detected two cases of fetal Down's syndrome and 4 cases with normal chromosomal aberrations. İn cases with with positive screen for trisomy 18 we detected a case with fetal Turner's syndrome. We concluded that using a lover cut off level unnecessary amniocentesis might be decreased.