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Online ISSN
1305-3132
Yayın Dönemi
1993 - 2021
Editor-in-Chief
Cihat Şen, Nicola Volpe
Editors
Daniel Rolnik, Mar Gil, Murat Yayla, Oluş Api
Cytokine levels in pregnant women with hyperemesis gravidarum
P. Balkanlı Kaplan , F. Güçer , N. C. Sayın , M. Yüksel , M. A. Yüce , T. Yardım
Künye
Cytokine levels in pregnant women with hyperemesis gravidarum. Perinatoloji Dergisi 2002;10(3):255-256
Yazar Bilgileri
- University of Trakya Department of Obstetrics and Gynecology Edirne TR
- University of Trakya Nuclear Medicine, Faculty of Medicine Edirne TR
Yayın Geçmişi
Çıkar Çakışması
Çıkar çakışması bulunmadığı belirtilmiştir.
Giriş
Overactivation of maternal immune system or high concentrations of trophoblast-derived cytokines may be responsible for the onset of first trimester pregnancy pathologies, including hyperemesis gravidarum. However, to our knowledge, there is no study evaluating maternal serum cytokine levels in patients with hyperemesis gravidarum. in the present study, we evaluated maternal serum concentrations of IL-1B, IL-2R, IL-6, IL-8, and TNF-a levels in patients with hyperemesis gravidarum and compared the levels with those in the healthy pregnant and non-pregnant women.
Yöntem
Bulgular
There was no significant difference in median matemal serum IL-2R and IL-8 levels within the three groups. in healthy pregnant patients, serum levels of IL-1b and IL-6 were significantly higher than that in the non-pregnant women. Median (range) TNF-a levels were significantly higher in hyperemesis group than the levels in healthy pregnant and non-pregnant women [25.8 pg/ml (4.9-140) vs. 10.85 pg/ml (4.1-35.8); 25.8 pg/ml (4.9-140) vs. 12 pg/ml (4.3-68.2)].
Sonuç
We found significantly elevated TNF-a levels in patients with hyperemesis gravidarum compared the levels in healthy pregnant and non-pregnant women. Elevated TNF-a levels may play a role in the etiology of hyperemesis gravidarum.
Overactivation of maternal immune system or high concentrations of trophoblast-derived cytokines may be responsible for the onset of first trimester pregnancy pathologies, including hyperemesis gravidarum. However, to our knowledge, there is no study evaluating maternal serum cytokine levels in patients with hyperemesis gravidarum. in the present study, we evaluated maternal serum concentrations of IL-1B, IL-2R, IL-6, IL-8, and TNF-a levels in patients with hyperemesis gravidarum and compared the levels with those in the healthy pregnant and non-pregnant women.
Yöntem
Whirty women with hyperemesis gravidarum, 30 women with healthy pregnancies in the first trimester, and 30 non-pregnant women were enrolled in the study, prospectively. Maternal serum IL-1b. IL-2R, IL-6, IL-8, and TNF-a levels were evaluated using two-site chemiluminescent enzyme immuneometric assay method in the three study groups.
Bulgular
There was no significant difference in median matemal serum IL-2R and IL-8 levels within the three groups. in healthy pregnant patients, serum levels of IL-1b and IL-6 were significantly higher than that in the non-pregnant women. Median (range) TNF-a levels were significantly higher in hyperemesis group than the levels in healthy pregnant and non-pregnant women [25.8 pg/ml (4.9-140) vs. 10.85 pg/ml (4.1-35.8); 25.8 pg/ml (4.9-140) vs. 12 pg/ml (4.3-68.2)].
Sonuç
We found significantly elevated TNF-a levels in patients with hyperemesis gravidarum compared the levels in healthy pregnant and non-pregnant women. Elevated TNF-a levels may play a role in the etiology of hyperemesis gravidarum.
Anahtar Kelimeler
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Makale Türü Bildiri Özeti |
|
Sayfalar 255-256 |
|
Künye |
| Perinatoloji Dergisi 2002; 10 (3) |
| PDF Olarak İndir |