Amaç
This project concerning Pb and Cd concentrations having influence on pregnency progress and outcomes was done in cooperation with Columbia University of New York. The area of Kosovksa Mitrovica and Zvecan is well-known for it's extra Pb and Cd air concentrations. These elements easaly penetrate the placental membrane so the aim was the follow up of pregnant women within the population living near the lead smelter. it has been suggested that accumulation of tobacco derived cadmium (Cd) in the placenta is responsible for the adverse effect of cigarette smoking on low birth weight.
Yöntem
Wee chose to test this hypothesis; therefore, we studied a population of nonsmoking pregnant women who were exposed to low levels of smelter-derived Cd and group of nonexposed women.
Bulgular
A higher mean placental Cd concentration (p< 0.00007) was found in the exposed women(n=106), compared with those who were non-exposed (n=55); the observed Cd concentrations were comparable to concentrations reported previously for smoking and nonsmoking women, espectively. Least squares multiple regression (controlling for potentially confounding variables) evealed no association between placental Cd and birthweight.
Sonuç
It was, therefore, concluded that the effect of smoking on birth weight was not mediated trough Cd.
Anahtar Kelimeler
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