The importance of maternal serum interleukin-6 concentrations in diagnosis of subclinical intrauterine infections in pregnant women with preterm labor

Amaç

To investigate the clinical imporlance of maternal serum interleukin-6 (il-6) measurements for diagnosis of asymptomatic intrauterine infection in women with preterm delivery.

Yöntem

 maternal serum il-6 concentrations have been measured in 61 pregnant women between 22. -34. Weeks of gestation. 39 were in preterm labor; 22 were in the control group. The placentas of 18 women who delivered in one week where tocolyses was not successful were sent to pathological analysis to investigate histological chorioamnionitis signs.

Bulgular

Average maternal serum il-6 concentrations of the group 1 with positive histochorioamnionitis and failing tocolyses who delivered in one week had been found significantly higher than in group 2 with successful tocolyses and positive histochorioamnionitis and in group 3 with failing tocolyses, who delivered in one week but had no signs of histochorioamnionitis (15 pg/ml versus 2.88 pg/ml and 6.40pg/ml). In order to predict preterm labor and histological chorioamnionitis during delivery, optimum sensitivity and specificity values of maternal serum il-6 concentrations have been found 5.9 pg/ml and above.

Tartışma

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