Neonatal screening of toxoplasmosis: A prospecttve study of 138 obstetrics patients

Yöntem

This prospeetive study consisted of 138 pregnant women and their infants who delivered between May 2001 and June 2002 at Obstetrics and Gynecology Department of Harran University Hospital. Blood samples were analyzed for the presence of Toxoplasma-spesific immunglobulin M (IgM) and G antibodies (lgG) by ELISA method. Blood samples of the newborns were collected by the first and the fifth days of their lifes. SPSS 11.02 for Windows was used for statistical analyzes.

Bulgular

The serologic test results of this study were demonstrated that at infants group 84 (60.9%) cases were IgG-positive and IgM-negative and 54 (39.1%) cases both IgG and IgM were negative. At mothers group 89 (64%) cases were IgG-positive, IgM-negative and 3 (2.2%) cases were found as IgG-negative and IgM-positive.

Sonuç

All newborns from mothers with antibody have passively acquired maternal IgG antibody whether the newborn is infected or not. IgM antibodies are not transferred across the placenta. Therefore demonstration of IgM antibodies in the newborn usually is sufficient to indicate active antenatal infection. Although we did not identify IgM by newborn screening, previous studies show that neonatal detection of Toxoplasma-spesific IgM antibodies is a feasible and practical method.

Anahtar Kelimeler

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