The correlation between lipids, hormons and proteinuria in women with asymp tomatic (İsolated) proteinuria in late pregnancy

The aim of the study was to evaluate the correlation between protein concentration in urine and the serum concentrations of lipids and chosen hormones in women with asymptomatic (isolated) proteinuria in late pregnancy.

Yöntem

The study covered 45 women with asymptomatic proteinuria. The women were at the mean age of 27.6+/-6,17 years and at 37,6+/-2,62 weeks of gestational age. Their mean arterial blood pressure was 123.0+/-15,4/76,l+/-12,0 mmHg, proteinuria - 2,02+/-l,95 g/24 hours, body mass index (BMI) before pregnancy - 23.8+/-2,79, BMI before labor - 29,9+/-3,8. On average, BMI increased 24,5+/-9,7%,. Three women presented lower extremities edema (6,67%). All women included in the study have had measured renal function biochemical parameters (uric acid, urea, osmolality, creatinine, electrolytes, acid base balance) and they have had done blood morphology parameters. Moreover, women included in the study had no urinal tract infection (no bacteriuria present, leucocyturia within normal limits). Laboratory tests revealed hypoproteinemia 58,0+/-5,0 g/l and hypoalbuminemia 443,4+/-58,0 umol/1. All women included in the study have had measured their serum concentrations of: total lipids (TL), total LDL fraction (TLDL), total cholesterol (TCh), free cholesterol (fCh), phospholipids (PhL, triglycerides (TG), HDL-cholesterol (HDL-cholesterol) and LDL-cholesterol (LDL-Ch), total estrogens (TE) and human placental lactogen (HPL). Moreover, fCh/TCh ratio, TCh/PhL and LDL/HDL-Ch ratios were calculated. Ther Pearson's correlation coefficient between proteinuria and above stated parameters was evaluated.

Bulgular The positive correlation was observed between proteinuria and: TL (r=0,43, p<0,003). TLDL (r=0,47, p<0,001), TCh (r=0,37, p<0,01), fCh (r=0,68, p<0,001), PhL (r+0,45, p<0,001), TG (r=0,50, p<0,001), HDL-Ch (r=0,34, p<0,002), fCh/TCh ratio (r=0,42, p<0,004). Moreover, the negative correlation was detected between proteinuria and: TE (r=0,31, p<0,05) and HPL (r=0,34, p<0,04)

Sonuç

İn women with asymptomatic (isolated) proteinuria, the observed increase in lipid parameters levels and decrease in TE and HPL serum concentrations with the degree of proteinuria.

Anahtar Kelimeler

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