Arşiv
Ara
Dergi Kimliği
Online ISSN
1305-3132
Yayın Dönemi
1993 - 2021
Editor-in-Chief
Cihat Şen, Nicola Volpe
Editors
Daniel Rolnik, Mar Gil, Murat Yayla, Oluş Api
The impact of low-dose aspirin therapy on umbilical and middle cerebral artery blood flow in pregnancy complicated by intrauterine growth restriction
J. Kalinka, M. Nowakowski , G. Leszek , W. Lech , T. Laudanski
Künye
The impact of low-dose aspirin therapy on umbilical and middle cerebral artery blood flow in pregnancy complicated by intrauterine growth restriction. Perinatoloji Dergisi 2002;10(3):220-220
Yazar Bilgileri
- Institute of Gynecology and Obstetrics, Medical University of Lodz Department of Perinatology Lodz PL
- Institute of Gynecology and Obstetrics, Medical University of Lodz Department of Gynecology and Gynecological Oncology Lodz PL
Yayın Geçmişi
Çıkar Çakışması
Çıkar çakışması bulunmadığı belirtilmiştir.
Amaç
Intrauterine growth restriction and its treatment still constitute a major clinical problem in perinatology. Since low doses of aspirin may improve the utero-placental circulation (by shifting the prostacyclin/tromboxan A2 balance), we have evaluated the impact of low-dose aspirin treatment of IUGR during pregnancy on umbilical (UA) and middle cerebral artery (MCA) blood flow.
Yöntem
The study group comprised 25 pregnant women with fetal intrauterine growth restriction (IUGR) diagnosed during pregnancy on the basis of ultrasound examination of biometric parameters (BPD, AC. FL). All the patients were treated only by low-dose aspirin (75-100 mg) for 10 days. The following examinations were performed before and after treatment: fetal biometry and calculation of blood flow indices in the umbilical and middle cerebral artery (S/D, RI, PI), together with selected maternal blood clotting parameters (bleeding time, clotting time, fibrinogen, platelets, APTT.
Bulgular
Mean values of all biometric parameters of the fetuses measured before and after treatment did not show statistically important differences except AC (p<0.1). Umbilical artery blood flow indices calculated after the treatment were slightly lower and MCA indices slightly higher, as compared to those before the treatment. Cerebro-placental ratio changed from 1.30 to 1.50 ( borderline significancy). The low-dose aspirin treatment did not produce any adverse effects neither among mothers nor infants.
Sonuç
1. IUGR treatment by low- dose aspirin had beneficial but non-significant impact on umbilical and middle cerebral artery blood flow. 2. Since the number of subjects in this study was relatively small, further clinical studies are necessary to evaluate the effectiveness of IUGR treatment by low dose aspirin. 3. Low-dose aspirin therapy in pregnant women did not produce any side effects for mothers or fetuses.
Intrauterine growth restriction and its treatment still constitute a major clinical problem in perinatology. Since low doses of aspirin may improve the utero-placental circulation (by shifting the prostacyclin/tromboxan A2 balance), we have evaluated the impact of low-dose aspirin treatment of IUGR during pregnancy on umbilical (UA) and middle cerebral artery (MCA) blood flow.
Yöntem
Bulgular
Mean values of all biometric parameters of the fetuses measured before and after treatment did not show statistically important differences except AC (p<0.1). Umbilical artery blood flow indices calculated after the treatment were slightly lower and MCA indices slightly higher, as compared to those before the treatment. Cerebro-placental ratio changed from 1.30 to 1.50 ( borderline significancy). The low-dose aspirin treatment did not produce any adverse effects neither among mothers nor infants.
Sonuç
1. IUGR treatment by low- dose aspirin had beneficial but non-significant impact on umbilical and middle cerebral artery blood flow. 2. Since the number of subjects in this study was relatively small, further clinical studies are necessary to evaluate the effectiveness of IUGR treatment by low dose aspirin. 3. Low-dose aspirin therapy in pregnant women did not produce any side effects for mothers or fetuses.
Anahtar Kelimeler
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Makale Türü Bildiri Özeti |
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Sayfalar 220-220 |
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Künye |
| Perinatoloji Dergisi 2002; 10 (3) |
| PDF Olarak İndir |