Arşiv
Ara
Dergi Kimliği
Online ISSN
1305-3132
Yayın Dönemi
1993 - 2021
Editor-in-Chief
Cihat Şen, Nicola Volpe
Editors
Daniel Rolnik, Mar Gil, Murat Yayla, Oluş Api
Serum fibronectin and no levels as an index of the endothelial damage in preeclampsia
Künye
Serum fibronectin and no levels as an index of the endothelial damage in preeclampsia. Perinatoloji Dergisi 2002;10(3):219-219
Yazar Bilgileri
- İnönü University Medical Faculty Department of Obstetrics and Gynecology Malatya TR
- İnönü University Medical Faculty Department of Clinical Biochemistry Malatya TR
Yayın Geçmişi
Çıkar Çakışması
Çıkar çakışması bulunmadığı belirtilmiştir.
Amaç
The aim of the study was to determine the presence and degree of endothelial injury by measuring plasma concentrations of cellular fibronectin (cFn) and circulating nitrate and total nitrite levels, end-products of Nitric Oxide, in pregnancies complicated by preeclampsia.
Yöntem
The aim of the study was to determine the presence and degree of endothelial injury by measuring plasma concentrations of cellular fibronectin (cFn) and circulating nitrate and total nitrite levels, end-products of Nitric Oxide, in pregnancies complicated by preeclampsia.
Yöntem
Circulating cellular fibronectin, nitrate and nitrite levels were compared between preeclamptic (n=20) and normotensive women (n=22). Two groups were similar at patients age, gestational age. Stored plasma, which had been obtained in ihe third trimester before labor, was assayed for cellular fibronectin by means of a sensitive and specific enzyme immunoassay, and serum nitrate, total nitrite levels measured by enzymatic Greiss reaction
Bulgular
The values of cFn were significantly higher (47.4 ± 27.9 mg/dl) in the third trimester in the group of women with preeclampsia, as compared to normals (26.8 ± 12.2 mg/dl). Sera from women with preeclampsia had significantly lower nitrate concentrations (24.16 ±3.12 vs 30.77 ±3.41, p<.0.05) compared with healthy pregnant women respectively controls, however, there were no significant differences at the serum total nitrite levels between two groups.
Sonuç
Pregnancies complicated by preeclampsia had significantly higher plasma cellular fibronectin concentrations, and significantly lower serum nitrate levels than did control pregnancies. We speculate that the combination of a deficiency of serum nitrate and an increase in cFN may directly or indirectly initiate the vast majority of physiological and serological changes associated with preeclampsia.
Bulgular
The values of cFn were significantly higher (47.4 ± 27.9 mg/dl) in the third trimester in the group of women with preeclampsia, as compared to normals (26.8 ± 12.2 mg/dl). Sera from women with preeclampsia had significantly lower nitrate concentrations (24.16 ±3.12 vs 30.77 ±3.41, p<.0.05) compared with healthy pregnant women respectively controls, however, there were no significant differences at the serum total nitrite levels between two groups.
Sonuç
Pregnancies complicated by preeclampsia had significantly higher plasma cellular fibronectin concentrations, and significantly lower serum nitrate levels than did control pregnancies. We speculate that the combination of a deficiency of serum nitrate and an increase in cFN may directly or indirectly initiate the vast majority of physiological and serological changes associated with preeclampsia.
Anahtar Kelimeler
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Makale Türü Bildiri Özeti |
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Sayfalar 219-219 |
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Künye |
| Perinatoloji Dergisi 2002; 10 (3) |
| PDF Olarak İndir |