Immunology reactivity and morphological peculiarities of peripheral blood neutrophyls in newborn sepsis

The immunologic status was studied in 250 prematures with sepsis during neonatal period. Ultrastructure of neutrophils in premature newborn was carried out in different phase of bacterial sepsis, neutrophiles functional activity, phase of bacterial sepsis, neutrophiles functional activity, peripheral blood neutrophiles morphological peculiarities were studied by phagocytosis with transmission electronic microscopy. We've assessed the concentration of fibronectine (FN) in blood and nitro-blue-tetrazolium (NBT) test. FN was studied by hardphaze immunoenzyme method with the use of affin antibodies and affinity chromatography. Patients were divided into following groups. I group included 130 first degree premature, II group 80 patients with second degree of prematurity, III -40 patients with third degree of prematurity. The results demonstrated structurai transformation of phagocytic function of neutrophils corresponding to phases and activity of sepsis. After Comparing our results in all groups, we conclude, that immune system of prematures with third degree of prematurity is more affected and it causes severe process of sepsis in these newborns. The results of the study showed correlation link between sepsis process, prognosis and immunologic changes. This gives the opportunity for early prognosis of sepsis and adequate management to prevent complications of the disease.