Herpes simplex virus (HSV) infectiüion diagnosis, clinic and outcome in newborns

A significant increase of frequency of congenital infections has been widely observed in these last decades. The rising process was due to development of the newest, sensitive diagnostic methods, widened scope of researched agents and increased number of infected fertile age woman, who may cause fetus congenital infection.
The aim of our research was to diagnose the HSV infection in newborns, to reveal clinical-immunological. echographic specifications and it's outcome. Screening on HSV infeetion was performed by detection of specific anti-HSV JgM antibodies by ELISA method. Positive ELISA results was considered to correspond to the primary HSV infection 45 newborns 0-1 months ot age with primary HSV infection were included in the study group. Among these infants 38 had generalized form, while 7 had CNS form of HSV infection. According to bacteriologic data patients were divided into two groups: first group included 19 infants with HSV mono-infection, while the second group included 26 infants with mixed infection. Associated bacterial pathogens were represented both by Gram-positive and Gram-negative bacteria and fungi. Almost all infants ((75%) vvith HSV infection had hepatomegaly with moderate hiperbilirubinemia, 17% of them diagnosed fetal hepatitis under prolonged and intensive jaundice of skin and mucose. 30% had splenomegaly. Respiratory system pathology as a pneumonia observed in 63% of patients. in majorily of them pneumonia was prolonged and complicated, almost always developing disseminated blood clotting syndrome. Clinical symptoms of various stages CNS pathology were noted in all patients, posthypoxie-ischemic encephalopathy were diagnosed to all of them. All these symptoms and syndromes were much more severe and frequent in the group of mixed infection. All patients with HSV underwent polytherapy including antiviral treatment (Aciclovir) on the background of immune, wide spread antibiotic and symptomatic therapy.

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