Arşiv
Ara
Dergi Kimliği
Online ISSN
1305-3132
Yayın Dönemi
1993 - 2021
Editor-in-Chief
Cihat Şen, Nicola Volpe
Editors
Daniel Rolnik, Mar Gil, Murat Yayla, Oluş Api
Preliminary report on a new and noninvasive method for the assessment of fetal lung maturity
Künye
Preliminary report on a new and noninvasive method for the assessment of fetal lung maturity. Perinatoloji Dergisi 2002;10(3):204-204
Yazar Bilgileri
- University "La Sapienza" Institute of Gynecology, Perinatology and Child Health Rome IT
Yayın Geçmişi
Çıkar Çakışması
Çıkar çakışması bulunmadığı belirtilmiştir.
Amaç
Yöntem
We prospectively enrolled 143 high-risk pregnancies in which a complete US study of FBMs and FLM tests were performed. Among them 43 women satisfied the inclusion criteria. US-FLM was defined as the presence of regular NFFVW detected by pulsed Doppler and spectral analysis, or irregular NFFVW synchronous with TWm detected by M-mode. An US guided amniocentesis was performed in order to collect amniotic fluid (AF) and FLM was evalııated by L/S (lecithin/sphingomyelin) determination, presence phosphatidylglycerol (PG) and lamellar bodies (LBs) count. At the end of the study diagnostic accuracy of US-FLM was compared with that of FLM tests.
Bulgular
Diagnostic accuracy for US evaluation of FLM was as follow: sensitivity: 89,6%; specificity: 85.7%; PPV 92,8%; NPV: 80%. Diagnostic accuracy of FLM tests was as follow: sensitivity: 100%; specificity: 51,7%; PPV 100%; NPV: 50%. L/S determination predieted lung maturity with a sensitivity of 100%; specificity 93,1%; PPV 100%; NPV 87,5%.
Sonuç
Presence of regular NFFVW or irregular NFFVW and TWm correlate accurately with conventional FLM tests. We suggest that this noninvasive procedure may be helpful to assess FLM, particularly under certain circumstances, e.g., oligo-anhydramnios, laboratory logistic equipment difficulties or heavily stained AF samples, amniocentesis refusal, religious concerns.
Several patterns of fetal breathing movements (FBMs) i.e., abdominal wall movements (AWm), thoracic wall movements (TWm), nasal fluid flow velocity waveforms (NFFVW) were investigated by ultrasound (US) technology and related to fetal pulmonary maturity and immaturity, i.e., fetal lung maturity (FLM) tests in order to validate the hypothesks that they may indicate that the fetal lung is mature or immature, regardless of gender, weight and gestational age.
Yöntem
We prospectively enrolled 143 high-risk pregnancies in which a complete US study of FBMs and FLM tests were performed. Among them 43 women satisfied the inclusion criteria. US-FLM was defined as the presence of regular NFFVW detected by pulsed Doppler and spectral analysis, or irregular NFFVW synchronous with TWm detected by M-mode. An US guided amniocentesis was performed in order to collect amniotic fluid (AF) and FLM was evalııated by L/S (lecithin/sphingomyelin) determination, presence phosphatidylglycerol (PG) and lamellar bodies (LBs) count. At the end of the study diagnostic accuracy of US-FLM was compared with that of FLM tests.
Diagnostic accuracy for US evaluation of FLM was as follow: sensitivity: 89,6%; specificity: 85.7%; PPV 92,8%; NPV: 80%. Diagnostic accuracy of FLM tests was as follow: sensitivity: 100%; specificity: 51,7%; PPV 100%; NPV: 50%. L/S determination predieted lung maturity with a sensitivity of 100%; specificity 93,1%; PPV 100%; NPV 87,5%.
Sonuç
Presence of regular NFFVW or irregular NFFVW and TWm correlate accurately with conventional FLM tests. We suggest that this noninvasive procedure may be helpful to assess FLM, particularly under certain circumstances, e.g., oligo-anhydramnios, laboratory logistic equipment difficulties or heavily stained AF samples, amniocentesis refusal, religious concerns.
Anahtar Kelimeler
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Makale Türü Bildiri Özeti |
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Sayfalar 204-204 |
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Künye |
| Perinatoloji Dergisi 2002; 10 (3) |
| PDF Olarak İndir |