Renal function in women with asymptomatic (isolated) roteinurıa in late pregnancy

Amaç

This study was conducted to analyze the renal function in women with asymptomatic (isolated) proteinuria in late pregnancy.

Yöntem

The study covered 45 women with asymptomalic proteinuria in late pregnancy (the study group) and 136 healthy women (the control group). Proteinuria was 2,02+/-l,95- vs 0,2+/-0,3 g/24 hours. Moreover, the women in both groups were at the same mean age: 27,6+/-6,17 vs 28,l+/-6,54 years (NS). The women in hoth group were also at the same gestational age: 37,6+/-2,62 vs 37,1+/- 2,15 (NS). Body mass inclex (BMI) before pregnancy was 23,8+/-2,79 vs 22,5+/- 2,60 (p<0,05). BMI before labor was 29,9+/-3,8 vs 27,7+/-2,8 (p<0,01). On average, BMI increased 24,5+/-9,7% vs 24,l+/-7,0 (NS). Mean arterial blood pressure was 123,0+/-15,4/76,1+/-12,0 mmHg vs 115+/-6,0/68,0+/-7,0 mmHg (p<0,01 and p<0,0l). Three women in the study group piesented lower extremities edema (6,67%). Moreover, all women inclucled in the study had no urinal tract infection (no bacteriuria present, leucocyturia within normal limits). Laboratory tests revealed hypoproteinemia 58,0+/-5,0 vs 67,0+/-6,0 g/l (p<0.001) and hypoalbuminemia 443,'i+/-58,() vs 522,0+/-87,0umol/l (p<(),001). All women inclucled in the study have had measured their serum concentrations of: uric acid (UA), urea (U), creatinine (Cr), electrolytes Na+, K+, C^l-, and Fe++, osmolality (which was measured also in urine), and blood morphology parameters.

Bulgular

 We observed - UA 26,7+/-7,9 vs 19.5+/-3.6 umol/1 (p<0,001), U 4,83 +/-1.91 vs 3,32+/-0,83 mmol/1 (p<0.001), Cr 85,7+/-12,3 vs 66,3+/-4,42umol/l (p<0,001), Na+ 140+/-2.2 vs 138+/-5.0 (p<0,001), K+ 4,37+/-0,37 vs 4,20+A0,2 (p<0,01), Cl- 109,5+/-2,4 vs 1O5+/-4 mmol/1 (p<0,001), Fe++ 22,0+/- 6.1 vs 16,4 +/- 2,2umol/l (p«),00D, osmolality in serum 282,8+/-3,7 vs 282,l+/-3,4 (NS), İn urine 650+/-185 vs 720+/-150 mOsm/kgII20 (NS), Hb 7,4l+/-0,7 vs 7,4l+/-0,68 mmol/1 (NS), erytrocytes 3,94 +/-O.36 vs 4,0+/-0,35 x 10_/l (NS), leucocytes 10,7+/-2,9 vs 10,8+/-2,0 x 10__/l (NS), hematocrit 33.1+/-3.25 vs 35,0 +/-3.0 % (p<0,01), platelets 198,6+/-46,9 vs 210,0+/-5,0 x 109/1 (NS).

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