Results and clinical outcome of pregnancies after preconception diagnosıs in 108 IVF cycles of Amercan Hospıtal

N. Erçelen, B. Balaban, A. Işıklar , E. Tutar, C. Alataş, A. Mumcu, S. Aksoy, R. Mercan , A. Nuhoğlu , B. Urman

Künye

Results and clinical outcome of pregnancies after preconception diagnosıs in 108 IVF cycles of Amercan Hospıtal. Perinatoloji Dergisi 2002;10(3):195-195

Yazar Bilgileri

N. Erçelen¹,

B. Balaban²,

A. Işıklar ²,

E. Tutar¹,

C. Alataş²,

A. Mumcu²,

S. Aksoy²,

R. Mercan ²,

A. Nuhoğlu ²,

B. Urman ²

American Hospital Genetics Department İstanbul TR
American Hospital Assisted Reproduction Unit İstanbul TR

Yayın Geçmişi

Çıkar Çakışması

Çıkar çakışması bulunmadığı belirtilmiştir.

Amaç

Preimplantation genetic diagnosis (PGD) of aneuploidy was performed on embryos of 108 patients undergoing IVF with identitication of either advanced maternal age, repeated implantation failures in IVF/ICSI or poor obstetric history usually in the form of recurrent abortion of no demonstrable cause or known genetic abnormality between April 2001 and June 2002.

Yöntem

For 108 ICSI/PGD/ET cycles, 586-day three embryos were biopsied and one blastomere from each was fixed for aneuploidy screening. MultiVysion PB (Vysis) hybridization kit was used for detection of chromosomes 13, 16, 18, 21, 22 and X, Y. Day five embryo transfer was performed for the embryos evaluated as normal.

Bulgular

Of the 586 embryos 372 (65%) were found aneuploid and the remaining 205 (35%) embryos were evaluated as euploid, resulting in day five blastocyst transfer. The aneuploidy rates for ehromosomes 13. 16, 18, 21, 22 and XY were as follows; 18%, 13%, 20%, 19%, 10%, 19%. A total of 141 embryos were transferred to 83 (77%) patients (mean 1.2; min: 1, max: 4). We achieved a positive pregnaney test on day 10 in 21 patients giving us a 19.4% pregnaney rate per cycle. Our clinical pregnaney rate per cycle and implantation rate per replaced embryo was 16.6% (18/108) and 12.7%; (18/141) respeetively. The ongoing pregnaney rate per PGD cycle was 11.9 (18/108) while five babies were delivered without any perinatal complications. All ongoing pregnancies were confirmed by prenatal diagnosis informing us that there was no misdiagnosis including the performed aneuploidy screening.

Sonuç

An inereased pregnancy rate was achieved by PGD of aneuploidy in poor prognosis IVF patients and also this technique may be recommended to overcome the complications of multiple pregnancies of IVF treatment by selecting the euploid and good quality embryos, which enables to decrease the number of transferred embryos.

Results and clinical outcome of pregnancies after preconception diagnosıs in 108 IVF cycles of Amercan Hospıtal

Künye

Yazar Bilgileri

Yayın Geçmişi

Çıkar Çakışması

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