Comparison of abortion, ectopic pregnancy and malformation rates in pregnancies after intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)

M. Benhabib, M. Karacan, A. Demircan, G. Saraç , O. Karabulut, E. Kervancıoğlu

Künye

Comparison of abortion, ectopic pregnancy and malformation rates in pregnancies after intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF). Perinatoloji Dergisi 2002;10(3):181-182

Yazar Bilgileri

M. Benhabib,

M. Karacan,

A. Demircan,

G. Saraç ,

O. Karabulut,

E. Kervancıoğlu

International Hospital Obstetrics and Gynecology Department İstanbul TR

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Amaç

After the introduction of assisted reproductive technologies (ART) possible effects of these procedures on the obstetric outcome have been investigated. Particularly, after the common use of ıntracytoplasmic sperm injection (ICSI) safety of this procedure has been criticized. Micromanipulation of the gametes might result in some problems such as unnatural seleetion of spermatozoon. exposure to reaetive oxygen species, meiotic spindle damage and/or introduction of toxic material into the oocyte. in the present study, we retrospectively compared abortion, ectopic pregnancy and malformation rates in pregnancies after ICSI and conventional IVF.

Yöntem

Between January 1995 to January 2000, 448 ICSI and 112 IVF pregnancies were compared. All pregnancies included were fresh embryo transfer cycles. Only couples with normal sperm analysis undercvent IVF.All couples with male factor (less then 5.000.000/ml total motile sperm) underwent ICSI cycle. Major malformation was defined as a condition requiring surgical correction or causing functional impairment.

Bulgular

Mean maternal age of women were 32+5.2 years for ICSI and 33.2+4.2 years for IVF group. in the first trimester, 143 pregnancies in ICSI group and 31 pregnancies in IVF group were lost giving the abortion rate of 31.8% and 27.6%, consecutively. Preclinical and clinical abortion rates were 15.4% and 16.5% in ICSI and 9.8% and 17.8% in IVF groups Ectopic pregnancy was diagnosed in 15 patients (3-2%) in ICSI and 2 patients (2.6%) in IVF group. All newborns (384 neonates in ICSI group and 104 neonates in IVF group) were examined by an experienced Pediatrician immediately after birth. Fourteen major congenital malformations were diagnosed in ICSI group (5 prenatally and 7 postnatally). in 3 pregnancies malformations (Down's Syndrome, Omphalocel, Hydrocephalus) were diagnosed in the second trimester by ultrasound and/or karyotyping and labor was induced. Three congenital malformations were diagnosed in IVF group after birth. Congenital malformation rate was similar in both groups (3.6% in IC¬SI and 2.8% in IVF group).

Sonuç

Abortion, ectopic pregnancy and congenital malformation rates in ICSI pregnancies did not differ from those obtained in conventional IVF pregnancies.

Comparison of abortion, ectopic pregnancy and malformation rates in pregnancies after intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)

Künye

Yazar Bilgileri

Yayın Geçmişi

Çıkar Çakışması

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