Cord blood IGF-1 and IGFBP-3 levels in asphyxıated newborns

Amaç

Determination and pathogenesis of perinatal asphyxia is stili an important problem in NICU. Aim of this study was to evaluate ıelationship between serum IGF-1, IGFBP-3 levels and perinatal asphyxia.

Yöntem

Perinatal asphyxia was evaluated by means of APGAR scores in 1 and 5 minutes and umbilical cord artery gas analysis as pH, PO2, PCO2, HCO3, ABE and lactate. According to these cri-teria 12 term-newborn infants were defined as asphyxiated and 11 newborns as normal. Umbilical cord blood IGF-1 and IGFBP-3 levels were deteeted and searched for correlation with Apgar scores and blo-od gas parameters.


Bulgular

Serum IGF-1 levels were lower in asphyxiated group than control subjects (27.2+ 26.1, 60.5 ±28.2, p<0.01). Serum IGFBP-3 levels were also lower in asphyxiated group (1107.7±320.4, l682.5±364.1, p<0.001). We demonstrated positive correlation between serum IGFBP-3 and Apgar scores (1 and 5 minute), pil, PCO2, ABE, HCO3, SO2, ctO2, and cord blood lactate levels. Cord blood IGF-1 levels were correlated with Apgar score at 1 minute, birth weight, and cord blood pH and HCO3 levels. Cord blood IGF-1 levels were correlated with birth weight and cord blood IGFBP-3 levels were correlated with cord blood HCO3 and ctO2 with stepwise regression analysis.

Sonuç Umbilical cord IGF-1 ancl IGFBP-3 levels decreased in asphyxiated newborns like in experimental studies. Correlation was found between IGF-1, IGFBP-3 levels and blood gas parameters. Because IGF-1 has neuroprotective effect in experimental models of hypoxia and isehemia, serum IGF-1 and : IGFBP-3 levels can be used for determination of asphyxia and may have possible protective effects when used as therapeutic agents.

Anahtar Kelimeler

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