Among various harmful factors of newborn's brain the main place takes hypoxy which causes deep metabolic and cerebrovascular disorders and is due to different kinds and severity of clinical manifestation of central nervous system (CNS) injury.
The aim of our study was to determine the injurious affect of hypoxic-ischemic factors upon the newborns brain, prognosing the correlations of clinical and ultrasonic patterns and CNS disorders. 198 full-term newborns in the age from 1 to 10 days were investigated. The ultrasonic investigation was produced on the devices of "Siemens Sonoline Elegra" and "Logic 700". Along with neurosonography cerebral hemodynamic was examined by using Colour Flow Mapping which permitted measurement the resistive index (RI), pulsatility index (PI), systolic and diastolic velocity in the anterior,middle, posterior and basilar arteries. in neonatal period the investigation was produced once per 10 days, later -once per month. Katamnestic period covered 1,5-2 years.
By clinical manifestation of CNS injury the patients in neonatal period were devided into 3 groups according to the course of disorder: mild, moderate and severe. The decrease of PI preceded the development of neurosonographic patterns of brain injury and clinical manifestation. The increased parametres of RI was observed in patients with intracranial hypertensy. in mild injuries clinical-dopplerographic disorders had transient character. in those newborns who were observed to have pathological findings of RI, PI and especially diastolic velocity of blood flow, subsequently developed brain leukomalacia and clinically was observed organic injury of CNS.
Sonuç
1. The decreased parameter of PI presents the high risk of development of brain hypoxic-ischemic injury.
2. Stable dopplerographic pathological patterns indicate to severity of brain injury and poor prognose.
3. Color Flow Mapping represents the high effective method for estimation the degree of brain's hypoxic-ischemic injury and prognosing the course of disease.
Anahtar Kelimeler
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