Evaluation of oxıdative stress

M. Arif Akşit

Künye

Evaluation of oxıdative stress. Perinatoloji Dergisi 2002;10(3):166-166

Yazar Bilgileri

M. Arif Akşit

Osmangazi University Medical Faculty Neonatology Department Eskişehir TR

Yazışma Adresi

M. Arif Akşit, Osmangazi University Medical Faculty Neonatology Department Eskişehir TR,

Yayın Geçmişi

Çıkar Çakışması

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Amaç

The main structure of living bodies is human cells. To evaluate the function of the cell (especially mitochondria) is nowadays indirectly estimated from the perspective of blood. The values a re differentiated in arterial, capillary, venous blood and in intercellular structure. İn order to make an exact estimation, all blood values have to altogether discuss under the patronage of clinical evaluation (including neurological, respiratory and other organ system functions, also concerning gut/liver, immune response).

Objectives:Blood gases a re classified as; a) Blood gases; pH, pCO2, pO2, b) Oxygenation: ctHb (Tolal blood hemoglobin concentration = cO2Hb-oxy + cHHb-deoxy + cCOHb-carboxy + cMetHb-met), Hctc, sO2 (Make correlation with ctHB, oxygen saturation = cO2Hb/cHHb + cO2Hb), FO2Hb (Oxyhemoglobin ratio = cO2Hb / cO2Hb + cHHb + cCOHb + cMetHb), FHHb, FmetHb, FetalHb, c) Electrolytes: Na, K, Ca, Cl, d)
Metabolic values: Glucose, lactate, bilirubin, mOsm, d) Status of oxygen: ctO2 (Content = Hb (g/dl) x 1.34 mI O2 / g Hb x saO2 x (0.003 mI O2/mmHg/dl), p50, e)
Acid-base status: cBase, cHCO3, ABE! SBE, AG (Anion gap = [Na + KJ - [Cl + HCO3J.
Design: The values will be taken arterial and venous simultaneously. After the treatment the values can be effect between 2-5 minutes. If you'll obtained no response, than change your approach. Don't just give intravenous fluid, but make reperfusion, prevent the baby from ischemic perfusion complications and edema.
Subjects: The values are not taken alone. We have to discuss the correlations with the concerning parameters. E.g. baby A with paO2 85 mmHg, saO2 95%, Hb 7 g/dl, is more hypoxemic than the other baby B with paO2 55 mmHg, saO2 85%, Hb 15 g/dl. CtO2 is 8.9 in baby A, but 17.1 mlO2/dl in baby B. Conciusion: All for one, one for all will be the main topic for evaluation of blood gases. All the components will be systematically examined and must make a correlation with the clinical findings.