Infants wıth neural tube defects: Maternal iymphocyte subpopulations during fregnancy

The objective of this study is to test the hypothesis that if maternal lymphocyte subpopulation changes occur during intrauterine period of pregnancies with neural tube defects (NTDs). We examined Maternal peripheral blood lymphocytes of eight mothers of the babies with NTDs and 25 pregnant women at the same gestational age were chosen as control group by flow-cytometry. We found some changes in the cellular immunity of the mothers of the babies with NTDs. The CD4/CD8 ratios were lower than those of control mothers (0.61±0.29, 0.84±0.29, respectively) (p=0.06). This difference was related to the decreased percentage of CD4+ cells found in mothers of the NTD group (21.21±7.59, 26.39±5.71 respectively) (p=0.07) and also the percentages of the CD(+ cells were also found to be increased (37,37±6.93,32.58±7.04 respectively), but it was not statistically significant (p=0.10). The pregnant women giving birth to babies with NTD may be more immune-suppressed than the women with normal pregnancies.

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