Arşiv
Ara
Dergi Kimliği
Online ISSN
1305-3132
Yayın Dönemi
1993 - 2021
Editor-in-Chief
Cihat Şen, Nicola Volpe
Editors
Daniel Rolnik, Mar Gil, Murat Yayla, Oluş Api
Antioxidant enzyme activıties in erythrocytes in maternal and fetal circulation in preeclampsia
Künye
Antioxidant enzyme activıties in erythrocytes in maternal and fetal circulation in preeclampsia. Perinatoloji Dergisi 1999;7(2):111-111
Yazar Bilgileri
- Inonu University School of Medicine Department of Biochemistry Malatya TR
- Inonu University School of Medicine Department of Obstetrics and Gynecology Malatya TR
Yazışma Adresi
Remzi Gökdeniz, Inonu University School of Medicine Department of Obstetrics and Gynecology Malatya TR,
Yayın Geçmişi
Çıkar Çakışması
Çıkar çakışması bulunmadığı belirtilmiştir.
Giriş
Free radical induced lipid peroxidation has been suggested as a possible pathogenic factor of preeclampsia. It was aimed to measure antioxidant enzyme activity in erythrocytes in maternal and fetal circulation in preeclamptic patients in the third trimester.
Yöntem
Maternal and umblical venous blood were obtained from thirty preeclamptic and thirty-one normotensif women with singletton pregnancy in the third trimester. The activities of glutathione peroxidase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD) were determined.
Bulgular
Patients ages and gestational weeks were not different in both groups (p>0.05). Whilst GSH-Px (U/gHb) and SOD-(U/gHb) were significantly higher (1857±131,2 vs 1387±123,8 and 2593,2±330.7 vs 2041±200,3, p<0.01), CAT (K/gHb) was significantly lower (71,2±18.1 vs 137,3±27,1) in erythrocyte of patients with preeclampsia and of controls (P<0.01). In umblical erythrocytes, SOD was significantly higher (1818.5±151.5 vs 1535.8±169.2, p<0.01) respectively, whereas CAT and GSH-Px were not different (84.8±14.3 vs 97.1±31.8 and 1207.5±117.5 vs 1211.41103.7, p>0.05). Independent t test was used for statistical significance. p<0.05 was set for significance.
Sonuç
These results demonstrate that increase in oxidative stress in preeclampsia results in development of defence mechanism both in maternal and fetal circulation to protect against reactive oxygen species. CAT has no impact on this protective effect in preeclampsia.
Free radical induced lipid peroxidation has been suggested as a possible pathogenic factor of preeclampsia. It was aimed to measure antioxidant enzyme activity in erythrocytes in maternal and fetal circulation in preeclamptic patients in the third trimester.
Yöntem
Maternal and umblical venous blood were obtained from thirty preeclamptic and thirty-one normotensif women with singletton pregnancy in the third trimester. The activities of glutathione peroxidase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD) were determined.
Bulgular
Patients ages and gestational weeks were not different in both groups (p>0.05). Whilst GSH-Px (U/gHb) and SOD-(U/gHb) were significantly higher (1857±131,2 vs 1387±123,8 and 2593,2±330.7 vs 2041±200,3, p<0.01), CAT (K/gHb) was significantly lower (71,2±18.1 vs 137,3±27,1) in erythrocyte of patients with preeclampsia and of controls (P<0.01). In umblical erythrocytes, SOD was significantly higher (1818.5±151.5 vs 1535.8±169.2, p<0.01) respectively, whereas CAT and GSH-Px were not different (84.8±14.3 vs 97.1±31.8 and 1207.5±117.5 vs 1211.41103.7, p>0.05). Independent t test was used for statistical significance. p<0.05 was set for significance.
Sonuç
These results demonstrate that increase in oxidative stress in preeclampsia results in development of defence mechanism both in maternal and fetal circulation to protect against reactive oxygen species. CAT has no impact on this protective effect in preeclampsia.
Anahtar Kelimeler
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Makale Türü Bildiri Özeti |
|
Sayfalar 111-111 |
|
Künye |
| Perinatoloji Dergisi 1999; 7 (2) |
| PDF Olarak İndir |