Placental adrenomedullin may play role in preeclampsia

Remzi Gökdeniz, Muhittin Yürekli

Künye

Placental adrenomedullin may play role in preeclampsia. Perinatoloji Dergisi 1999;7(2):109-109

Yazar Bilgileri

Remzi Gökdeniz¹,

Muhittin Yürekli²

Inonu University , School of Medicine Department of Obstetrics and Gynecology Malatya TR
Inonu University Science-Literature Faculty Molecular Biology Malatya TR

Yazışma Adresi

Remzi Gökdeniz, Inonu University , School of Medicine Department of Obstetrics and Gynecology Malatya TR,

Yayın Geçmişi

Çıkar Çakışması

Çıkar çakışması bulunmadığı belirtilmiştir.

Giriş

Adrenomedullin(AdM)is a novel peptide with long-lasting hypotensive effect by providing vasorelaxation. İt is expressed in several tissues, including adrenal medulla,heart,lung,kidneys,and cultured vascular smooth muscle cells. Also in large amounts it is present in amniotic fluid and cord blood.İt was aimed to assess placental adrenomedullin levels in preeclampsia.
Yöntem
Placental tissues were collected from seven preeclamptic patients and ten healty gravidas. Tissue concentration of rat AdM in placental tissues was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set as p<0.

Bulgular

AdM concentrations were 136.25±7.61 pmol and 172.62±7.34 pmol in preeclampsia and healty gravidas respectively. This was significant (p<0.05).

Sonuç

We have found marked low level of AdM in placentas from preeclamptic patients. These data suggest that placenta is a site -of synthesis in pregnancy and low production of AdM may be responsible for the observed placental pathology in preeclampsia.