Maternal Serum Uric Acid Levels In Predicting Preclamsia in Twin Gestations

Amaç

We aimed to establish a cut-off value for serum uric acid level in twin and singleton gestations to predict the risk of preeclampsia.

Yöntem

21 nonmotensive and 16 preeclamptic women with twin gestations, who had no underiying chronic hypertension or renal insufficiency, had serum uric acid levels measured on admission to the labor and delivery unif. These levels were compared with those of 56 nonmotensive and 43 preeclamptic singleton gravidas admitted to the same unit. A receiver operating characteristic (ROC) curve was used to determine the optimal maternal serum uric acid cut-off value for twins to predict the high risk patlents for preeclampsia and to compare this value with that of singleton gestations.

Bulgular

 Women with non-preeclamptic twin pregnancies had a median serum uric acid concentration of 4.1 mg/dl (range: 3.4 to 5.3) while those women with non-preeclamptic singleton pregnancies had a median of 4.25 mg/dl. (range: 3.4 to 6.1), p>0.05. Singletons (median: 6.65 mg/dl, range: 3.8 to 9.7; median: 6.9 mg/dl, range: 3.7 to 10.4 respectively), p> 0.05. Using ROC curves, we determined that a maternal serum uric acid level of 5,3 mg/dl appeared to be the optimal cut-off value for identifying preeclampsia in twin gestations with a sensitivity of 75 % and specifity of 100 % and 5,1 mg/dl appeared to be the optimal cut-off value for identifying preeclampsia in singleton gestations, with a sensitivity 91 % and a specifity of 87 %.

Sonuç

Preeclamptic women have significanty higher serum uric acid levels than non-preeclamptic women both in twin and singleton gestations. There were no statistically significant difference in serum uric acid levels between twin and singleton gestations with or without preeclampsia which suggests no need to find a separate normative value for twin gestations.

Anahtar Kelimeler

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