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Dergi Kimliği
Online ISSN
1305-3132
Yayın Dönemi
1993 - 2021
Editor-in-Chief
Cihat Şen, Nicola Volpe
Editors
Daniel Rolnik, Mar Gil, Murat Yayla, Oluş Api
Erythropoietin prevents ischemia-reperfusion induced oxidative damage in fetal rat brain
A. Solaroğlu , İ. Solaroğlu , E. Kaptanoğlu , S. Dede , O. Tan , E. Beskonaklı , A. Haberal , K. Kılınç
Künye
Erythropoietin prevents ischemia-reperfusion induced oxidative damage in fetal rat brain. Perinatoloji Dergisi 2002;10(3):252-252
Yazar Bilgileri
- Social Insurance Institution, Ankara Maternity and Women's Health Teaching Hospital Department of Obstetrics and Gynecology Ankara TR
- Ankara Numune Research and Educational Hospital Department of Neurosurgery Ankara TR
- Hacettepe University, Faculty of Medicine Department of Biochemistry Ankara TR
Yayın Geçmişi
Çıkar Çakışması
Çıkar çakışması bulunmadığı belirtilmiştir.
Amaç
The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion induced oxidative damage in fetal rat brain.
Yöntem
Fetal brain ischemia was induced by damping the utero-ovarian artery bilaterally for 20 minutes and reperfusion was achieved by removing the clamps for 30 minutes. in control group, non-injured 19 day pregnant rats were used. in ischemia-reperfusion group, no treatment was given. 0.4 ml of human serum albumin solution and 5000 U/kg recombinant human erithropoietin (r-Hu-EPO) were administered in vehicle and treatment groups 30 min. before ischemia-reperfusion injury. Lipid peroxidation in the brain tissue was determined as thiobarbituric acid reactive substances (TBARS) concentration for each fetal rat. The one-way analysis of variance and post-hoc test were used for statistical analysis.
Bulgular
TBARS increased statistically significant levels in fetal rat brain after ischemia-reperfusion injury comparing to control group. Recombinant human erythropoietin prevented increase in TBARS in ischemia-reperfusion injury.
Sonuç
Recombinant human erythropoietin has been shown to have neuroprotective effect in intrauterine ischemia-reperfusion induced fetal brain damage in rats.
The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion induced oxidative damage in fetal rat brain.
Yöntem
Fetal brain ischemia was induced by damping the utero-ovarian artery bilaterally for 20 minutes and reperfusion was achieved by removing the clamps for 30 minutes. in control group, non-injured 19 day pregnant rats were used. in ischemia-reperfusion group, no treatment was given. 0.4 ml of human serum albumin solution and 5000 U/kg recombinant human erithropoietin (r-Hu-EPO) were administered in vehicle and treatment groups 30 min. before ischemia-reperfusion injury. Lipid peroxidation in the brain tissue was determined as thiobarbituric acid reactive substances (TBARS) concentration for each fetal rat. The one-way analysis of variance and post-hoc test were used for statistical analysis.
Bulgular
TBARS increased statistically significant levels in fetal rat brain after ischemia-reperfusion injury comparing to control group. Recombinant human erythropoietin prevented increase in TBARS in ischemia-reperfusion injury.
Sonuç
Recombinant human erythropoietin has been shown to have neuroprotective effect in intrauterine ischemia-reperfusion induced fetal brain damage in rats.
Anahtar Kelimeler
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Makale Türü Bildiri Özeti |
|
Sayfalar 252-252 |
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Künye |
| Perinatoloji Dergisi 2002; 10 (3) |
| PDF Olarak İndir |