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Dergi Kimliği

Online ISSN
1305-3132

Yayın Dönemi
1993 - 2021

Editor-in-Chief
​Cihat Şen, ​Nicola Volpe

Editors
Daniel Rolnik, Mar Gil, Murat Yayla, Oluş Api

Prenatal diagnosis of Down Syndrome in a twin pregnancy: The role of second trimester ultrasonography

E. Müngen , L. Tütüncü , Y.Z. Yergök , Ö. Dündar

Künye

Prenatal diagnosis of Down Syndrome in a twin pregnancy: The role of second trimester ultrasonography. Perinatoloji Dergisi 2002;10(3):239-239

Yazar Bilgileri

E. Müngen ,
L. Tütüncü ,
Y.Z. Yergök ,
Ö. Dündar

  1. Gülhane Military Medical Academy, Haydarpaşa Hospital - İstanbul TR
Yayın Geçmişi
Çıkar Çakışması

Çıkar çakışması bulunmadığı belirtilmiştir.

Amaç

Multiple gestations are at increased risk for congenital abnormalities. The role of second trimester maternal serum biochemical screening for chromosomal abnormalities in multiple gestations is limited. For these reasons, prenatal identification of fetuses with structural and/or chromosomal abnormalities in mutifetal pregnancies is a diagnostic challenge. The aim of this case report is to emphasize the role of second trimester targeted ultrasonography in the prenatal diagnosis of fetal abnormalities in multiple gestations.

Olgu

Detailed fetal ultrasonographic examination in a 27-year-old woman with twin pregnancy at 16 weeks' gestation revealed thickened nuchal fold (8 mm) in one of the fetuses. The other was normal. Amniocentesis was performed with two separate needle insertions into the two gestational sacs. The karyotype of the fetus with thickened nuchal fold was 47, XY, +21 (Down syndrome) and that of the the other was normal. The parents were counselled regarding the possibility of selective termination because dichorionic placentation and opted to terminate the affected twin. Selective termination of the fetus with Down syndrome was performed by intracardiac potassium chloride injection at 19 weeks of gestation. The remainder of pregnancy was uneventful and the healty baby was delivered by cesarean section at 39 weeks of gestation.

Sonuç
 
Second trimester targeted ultrasonography has an important place in fetal anomaly screening in multiple pregnancies. Key words: Multiple gestation, Down syndrome, selective termination.
Anahtar Kelimeler

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